National University of Singapore

A university lecture tracing the path from molecular clock mechanisms to interventions that can actually be tested in people, the translation problem that sits at the centre of Dr Panda's career.

The material moves through the layers in order. What sets the pace of the clock, including the links between NAD metabolism, the ROR nuclear hormone receptors, chromatin regulation and clock speed. How the clock is aligned to the outside world, through melanopsin mediated light sensing in the eye and through feeding signals that reach the liver and gut. What the clock then regulates, mapped across tissues by time series studies of gene expression. And finally what can be changed: light, sleep timing and the eating window, tested in humans through clinical trials and through app based studies at scale.

Pitched for an academic audience but broad enough to follow without specialist background. A useful overview of how one line of basic research became a public health proposition.