Science, time and human health

20269 papers

2026 . J AM MED INFORM ASSOCNutriRAG: unleashing the power of large language models for food identification and classification through retrieval methods2026 . OBESITY (SILVER SPRING)Time-Restricted Eating Promotes Weight Loss and Favorable Changes in Adipose in Obesity: The TREAD Randomized Control Trial2026 . NAT METABThe diversity and consistency of what and when people eat2026 . INQUIRYComparison of Self-Reported Dietary Recalls and Real-Time Tools to Track Mealtimes in Older Adults: A Pilot Study2026 . BIORXIVTime Restricted Feeding Mitigates High-Fat-Diet Induced Sleep Disruption and Amplifies NREM Substates2026 . JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICSRelative Effects of Time-Restricted Eating, Energy-Restricted Eating, and Unrestricted Eating on Eating Patterns and Dietary Intake: Results From a Randomized Controlled Trial2026 . INT J OBES (LOND)Post-intervention sustainability of time-restricted eating versus caloric restriction: a secondary analysis2026 . SCIENTIFIC REPORTSNeuropsin-expressing cells in the retina affect melanopsin expression and response to light in mice2026 . HANDBOOK OF CLINICAL NEUROLOGYRetinal ganglion cells expressing melanopsin

202512 papers

2025 . SCIENCEBile acid synthesis impedes tumor-specific T cell responses during liver cancer2025 . METABOLOMICSBlood metabolomics improves prediction of central nervous system damage in multiple sclerosis2025 . CELL HOST & MICROBEMetatranscriptomics Uncover Diurnal Functional Shifts in Bacterial Transgenes with Profound Metabolic Effects2025 . CELL GENOMGenome-wide allele-specific expression in multi-tissue samples from healthy male baboons reveals the transcriptional complexity of mammals2025 . OBESITY (SILVER SPRING)Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial2025 . DIABETES METAB SYNDRShort-term 24h dietary recalls from observational studies cannot support claims on mortality2025 . BMC NUTRTake the reins: a study protocol of a randomized controlled trial testing the effects of time-restricted eating vs. nutrition control on cancer-related fatigue among survivors of hematological malignancies2025 . SCIENTIFIC REPORTSTime-restricted eating improves quality of life, heart rate, and mitochondrial function in patients with postural orthostatic tachycardia syndrome. An open-label pilot study2025 . NUTRIENTSBiological vs. Chronological Overnight Fasting: Influence of Last Evening Meal on Morning Glucose in Dysglycemia2025 . NAT METABThe time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research2025 . FRONT PHARMACOLLateral habenula astroglia modulate the potentiating antidepressant-like effects of bright light stimulation in intractable depression2025 . NUTR RESComparing the effectiveness of calorie restriction with and without time-restricted eating on the circadian regulation of metabolism: rationale and protocol of a three-arm randomised controlled trial in adults at risk of type 2 diabetes

20248 papers

2024 . TRENDS CANCERLearning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care2024 . CELL METABOLISMMulti-organ transcriptome atlas of a mouse model of relative energy deficiency in sport2024 . CELL REPORTSEnergy balance drives diurnal and nocturnal brain transcriptome rhythms2024 . LANCET HEALTHY LONGEVEffects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial2024 . ANNALS OF INTERNAL MEDICINETime-Restricted Eating in Adults With Metabolic Syndrome: A Randomized Controlled Trial2024 . CELL METABOLISMInternational consensus on fasting terminology2024 . ISCIENCENeuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development2024 . ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGYTime-Restricted Feeding Reduces Atherosclerosis in LDLR KO Mice but Not in ApoE Knockout Mice

202314 papers

2023 . OBESITY (SILVER SPRING)Time-restricted eating alters the 24-hour profile of adipose tissue transcriptome in men with obesity2023 . LIFE SCI ALLIANCEReciprocal regulation between the molecular clock and kidney injury2023 . OBESITY (SILVER SPRING)The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial2023 . THE JOURNALS OF GERONTOLOGY SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCESTargeting Energy Intake and Circadian Biology to Engage Mechanisms of Aging in Older Adults With Obesity: Calorie Restriction and Time-Restricted Eating2023 . CELL MOL GASTROENTEROL HEPATOLThe Untapped Potential of Circadian Timing as a Variable for Discoveries and Reproducibility2023 . CELL METABOLISMWhen a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging2023 . NATURE COMMUNICATIONSTime-restricted feeding promotes muscle function through purine cycle and AMPK signaling in Drosophila obesity models2023 . CELL REP MEDDynamic activity in cis-regulatory elements of leukocytes identifies transcription factor activation and stratifies COVID-19 severity in ICU patients2023 . BR J NUTRPredicting energy intake with an accelerometer-based intake-balance method2023 . NATUREInsulin-regulated serine and lipid metabolism drive peripheral neuropathy2023 . J PINEAL RESDaytime light exposure is a strong predictor of seasonal variation in sleep and circadian timing of university students2023 . CELL METABOLISMDiurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals2023 . ENEUROUltrastructure of Synaptic Connectivity within Subregions of the Suprachiasmatic Nucleus Revealed by a Genetically Encoded Tag and Serial Blockface Electron Microscopy2023 . OBESITY (SILVER SPRING)Time-restricted eating did not alter insulin sensitivity or beta-cell function in adults with obesity: A randomized pilot study

202217 papers

2022 . BR J NUTREating architecture in adults at increased risk of type 2 diabetes: associations with body fat and glycaemic control2022 . NUTRITIONTime-restricted eating improves glycemic control and dampens energy-consuming pathways in human adipose tissue2022 . CELL REP MEDTime for better time-restricted eating trials to lessen the burden of metabolic diseases2022 . CELL METABOLISMFocus on diet and exercise2022 . FRONT NUTRThe impact of a self-selected time restricted eating intervention on eating patterns, sleep, and late-night eating in individuals with obesity2022 . CONTEMPORARY CLINICAL TRIALSTime-restricted eating to improve cardiometabolic health: The New York Time-Restricted EATing randomized clinical trial - Protocol overview2022 . FRONT NUTRBarriers to adherence in time-restricted eating clinical trials: An early preliminary review2022 . CELL METABOLISMFeasibility of time-restricted eating and impacts on cardiometabolic health in 24-h shift workers: The Healthy Heroes randomized control trial2022 . INT J OBES (LOND)Assessing temporal eating pattern in free living humans through the myCircadianClock app2022 . ENDOCR REVTime-restricted eating for the prevention and management of metabolic diseases2022 . NATURE REVIEWS ENDOCRINOLOGYTime-restricted feeding and circadian autophagy for long life2022 . N ENGL J MEDCalorie and Time Restriction in Weight Loss2022 . EXPERIMENTAL GERONTOLOGYAssociations between the timing of eating and weight-loss in calorically restricted healthy adults: Findings from the CALERIE study2022 . SCIENCEAligning mealtimes to live longer2022 . CELL REPORTSDiet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome2022 . TRENDS NEUROSCIOcular and extraocular roles of neuropsin in vertebrates2022 . NATURERevival of light signalling in the postmortem mouse and human retina

202110 papers

2021 . PROC NATL ACAD SCI USAA genome-wide microRNA screen identifies the microRNA-183/96/182 cluster as a modulator of circadian rhythms2021 . NUTRIENTSPilot Clinical Trial of Time-Restricted Eating in Patients with Metabolic Syndrome2021 . NUTRIENTSA Smartphone Intervention to Promote Time Restricted Eating Reduces Body Weight and Blood Pressure in Adults with Overweight and Obesity: A Pilot Study2021 . NUTRIENTSTemporal Eating Patterns and Eating Windows among Adults with Overweight or Obesity2021 . NUTRIENTSThe Effects of Time-Restricted Eating versus Standard Dietary Advice on Weight, Metabolic Health and the Consumption of Processed Food: A Pragmatic Randomised Controlled Trial in Community-Based Adults2021 . BMJ OPENProtocol for a randomised controlled trial on the feasibility and effects of 10-hour time-restricted eating on cardiometabolic disease risk among career firefighters doing 24-hour shift work: the Healthy Heroes Study2021 . NUTRIENTSTime-Restricted Eating for 12 Weeks Does Not Adversely Alter Bone Turnover in Overweight Adults2021 . J BIOL RHYTHMSA Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care2021 . NUTRIENTSTime-Restricted Eating Improves Quality of Life Measures in Overweight Humans2021 . CELL REPORTSSex- and age-dependent outcomes of 9-hour time-restricted feeding of a Western high-fat high-sucrose diet in C57BL/6J mice

20205 papers

2020 . CELL METABOLISMTen-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome2020 . BMJ OPENProtocol for a single-centre, parallel-group, randomised, controlled, superiority trial on the effects of time-restricted eating on body weight, behaviour and metabolism in individuals at high risk of type 2 diabetes: the REStricted Eating Time (RESET) study2020 . NUTRIENTSTime-Restricted Eating Alters Food Intake Patterns, as Prospectively Documented by a Smartphone Application2020 . J CLIN ENDOCRINOL METABNew Horizons: Circadian control of metabolism offers novel insight into the cause and treatment of metabolic diseases2020 . OBESITY (SILVER SPRING)Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study

201913 papers

2019 . NATURE COMMUNICATIONSTime-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption2019 . TRENDS CANCERInterplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment2019 . NATURE REVIEWS ENDOCRINOLOGYThe arrival of circadian medicine2019 . SCIENCEFunctional diversity of human intrinsically photosensitive retinal ganglion cells2019 . J BIOL RHYTHMSWhen to Eat: The Importance of Eating Patterns in Health and Disease2019 . CELL REPORTSSynaptic Specializations of Melanopsin-Retinal Ganglion Cells in Multiple Brain Regions Revealed by Genetic Label for Light and Electron Microscopy2019 . OBESITY (SILVER SPRING)Time-Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial2019 . CELL METABOLISMAlternate-Day Fasting Gets a Safe Bill of Health2019 . CELL REPORTSGenetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD2019 . DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATIONProspective association between late evening food consumption and risk of prediabetes and diabetes: the Whitehall II cohort study2019 . NATURE REVIEWS ENDOCRINOLOGYTiming tweaks exercise2019 . ANNU REV NUTRTime-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases2019 . CELL METABOLISMTime-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

20188 papers

2018 . NATURE COMMUNICATIONSAntibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism2018 . NATUREPharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence2018 . TRENDS PHARMACOL SCITraining the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases2018 . SCIENCEDiurnal transcriptome atlas of a primate across major neural and peripheral tissues2018 . CELL REPORTSSustained Melanopsin Photoresponse Is Supported by Specific Roles of beta-Arrestin 1 and 2 in Deactivation and Regeneration of Photopigment2018 . NUTR HEALTHY AGINGEffects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study2018 . SCI ADVSleepmore in Seattle: Later school start times are associated with more sleep and better performance in high school students2018 . CELL METABOLISMThe RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding

20174 papers

2017 . J PHYSIOLTime-restricted feeding for prevention and treatment of cardiometabolic disorders2017 . SCI TOTAL ENVIRONHealth consequences of electric lighting practices in the modern world: A report on the National Toxicology Program's workshop on shift work at night, artificial light at night, and circadian disruption2017 . NPJ AGING MECH DISGlobal rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies2017 . PLOS ONEA camera-phone based study reveals erratic eating pattern and disrupted daily eating-fasting cycle among adults in India

201610 papers

2016 . TRENDS ENDOCRINOL METABDaily Eating Patterns and Their Impact on Health and Disease2016 . SCIENCECircadian physiology of metabolism2016 . NEURONMelanopsin-Encoded Response Properties of Intrinsically Photosensitive Retinal Ganglion Cells2016 . AGEING RES REVCircadian rhythms, time-restricted feeding, and healthy aging2016 . PROC NATL ACAD SCI USACircadian clock, nutrient quality, and eating pattern tune diurnal rhythms in the mitochondrial proteome2016 . CELL METABOLISMFasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan2016 . PLOS ONEIntrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) Are Necessary for Light Entrainment of Peripheral Clocks2016 . J CELL BIOLThe circadian coordination of cell biology2016 . TRENDS ENDOCRINOL METABKetone Bodies Signal Opportunistic Food-Seeking Activity2016 . ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGYRNA Dynamics in the Control of Circadian Rhythm

20154 papers

2015 . FASEB JCircadian timing in central and peripheral tissues in a migratory songbird: dependence on annual life-history states2015 . CELL METABOLISMA Smartphone App Reveals Erratic Diurnal Eating Patterns in Humans that Can Be Modulated for Health Benefits2015 . SCIENCETime-restricted feeding attenuates age-related cardiac decline in Drosophila2015 . SLEEPImpact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions

20149 papers

2014 . CELL METABOLISMDiet and feeding pattern affect the diurnal dynamics of the gut microbiome2014 . NEURONExperience-dependent remodeling of basket cell networks in the dentate gyrus2014 . FRONTIERS IN NEUROANATOMYA workflow for the automatic segmentation of organelles in electron microscopy image stacks2014 . PROC NATL ACAD SCI USAMeal frequency and timing in health and disease2014 . J NEUROSCIT-box Transcription Regulator Tbr2 Is Essential for the Formation and Maintenance of Opn4/Melanopsin-Expressing Intrinsically Photosensitive Retinal Ganglion Cells2014 . CELL REPORTSPER1 phosphorylation specifies feeding rhythm in mice2014 . ELIFELhx1 maintains synchrony among circadian oscillator neurons of the SCN2014 . CELL METABOLISMTime-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges2014 . MICROSCOPY AND MICROANALYSIS : THE OFFICIAL JOURNAL OF MICROSCOPY SOCIETY OF AMERICA, MICROBEAM ANALYSIS SOCIETY, MICROSCOPICAL SOCIETY OF CANADAX-Ray Microscopy as an Approach to Increasing Accuracy and Efficiency of Serial Block-Face Imaging for Correlated Light and Electron Microscopy of Biological Specimens

20136 papers

2013 . PROC NATL ACAD SCI USALocal circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling2013 . NATURE CHEMICAL BIOLOGYSmall-molecule antagonists of melanopsin-mediated phototransduction2013 . EMBO REPNucleosome dynamics regulate Neurospora circadian clock2013 . CURR OPIN NEUROBIOLCircadian timekeeping and output mechanisms in animals2013 . PLOS BIOLCo-expression of VAL- and TMT-opsins uncovers ancient photosensory interneurons and motorneurons in the vertebrate brain2013 . J BIOL RHYTHMSAberrant development of the suprachiasmatic nucleus and circadian rhythms in mice lacking the homeodomain protein Six6

20126 papers

2012 . CELL METABOLISMCircadian Oscillations of Protein-Coding and Regulatory RNAs in a Highly Dynamic Mammalian Liver Epigenome2012 . NAT NEUROSCITranscriptional code and disease map for adult retinal cell types2012 . PROC NATL ACAD SCI USACircadian clock protein cryptochrome regulates the expression of proinflammatory cytokines2012 . NEURONFear of the light or need for action: the IGL will judge2012 . CELL METABOLISMTime-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet2012 . NATURERegulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta

20115 papers

2011 . MOLECULAR PSYCHIATRYAltered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the beta2 nicotinic receptor2011 . CURR BIOLMolecular organization of Drosophila neuroendocrine cells by Dimmed2011 . EMBO JTemporal orchestration of circadian autophagy rhythm by C/EBPbeta2011 . CELL METABOLISMFeeding mistiming decreases reproductive fitness in flies2011 . SCIENCEHistone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock

20104 papers

2010 . PROC NATL ACAD SCI USAJumonji domain protein JMJD5 functions in both the plant and human circadian systems2010 . CELL RESEARCHCRY links the circadian clock and CREB-mediated gluconeogenesis2010 . TRENDS MOL MEDThe emerging roles of melanopsin in behavioral adaptation to light2010 . PLOS BIOLMelanopsin contributions to irradiance coding in the thalamo-cortical visual system

20095 papers

2009 . PROC NATL ACAD SCI USATime of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression2009 . SCIENCEAMPK regulates the circadian clock by cryptochrome phosphorylation and degradation2009 . PLOS GENETHarmonics of circadian gene transcription in mammals2009 . PROC NATL ACAD SCI USAFunctional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes2009 . PLOS BIOLNetwork features of the mammalian circadian clock

20084 papers

2008 . SIGNAL TRANSDUCTION IN THE RETINA (CRC PRESS)Melanopsin signaling and nonvisual ocular photoreceptionBook chapter

2008 . PLOS ONEA high-throughput assay for siRNA-based circadian screens in human U2OS cells2008 . PROC NATL ACAD SCI USARestoration of visual function in retinal degeneration mice by ectopic expression of melanopsin2008 . PLOS ONEInducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses

20076 papers

2007 . PROC NATL ACAD SCI USAReciprocity between phase shifts and amplitude changes in the mammalian circadian clock2007 . NEURONMultiple photopigments entrain the Mammalian circadian oscillator2007 . CELL MOL LIFE SCIRole of a novel photopigment, melanopsin, in behavioral adaptation to light2007 . PROC NATL ACAD SCI USACircadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation2007 . NAT GENETThe imprinted gene Magel2 regulates normal circadian output2007 . COLD SPRING HARB SYMP QUANT BIOLHigh-resolution Time Course Analysis of Gene Expression from Pituitary

20061 paper

2006 . J BIOL RHYTHMSSystems biology of circadian rhythms: an outlook

20052 papers

2005 . CIRCULATIONBioinformatic analysis of circadian gene oscillation in mouse aorta2005 . SCIENCEIllumination of the melanopsin signaling pathway

20043 papers

2004 . NEURONA functional genomics strategy reveals Rora as a component of the mammalian circadian clock2004 . PLOS BIOLBMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis2004 . J BIOL CHEMThe transcriptional repressor STRA13 regulates a subset of peripheral circadian outputs

20035 papers

2003 . J BIOL RHYTHMSDNA arrays: applications and implications for circadian biology2003 . TRENDS CELL BIOLAn array of insights: application of DNA chip technology in the study of cell biology2003 . SCIENCEMelanopsin is required for non-image-forming photic responses in blind mice2003 . NOVARTIS FOUND SYMPCircadian light input in plants, flies and mammals2003 . NOVARTIS FOUND SYMPCircadian transcriptional output in the SCN and liver of the mouse

20025 papers

2002 . SCIENCEMelanopsin (Opn4) requirement for normal light-induced circadian phase shifting2002 . DEV CELLtej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator2002 . NATURECircadian rhythms from flies to human2002 . CELLCoordinated transcription of key pathways in the mouse by the circadian clock2002 . J NEUROSCIGenome-wide expression analysis in Drosophila reveals genes controlling circadian behavior

20012 papers

2001 . ANNU REV CELL DEV BIOLMolecular bases of circadian rhythms2001 . PLANT CELLELF3 modulates resetting of the circadian clock in Arabidopsis

20002 papers

2000 . SCIENCECloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog2000 . NATUREFunctional interaction of phytochrome B and cryptochrome 2